Nlrp9b Protein (AA 1-1003) (His tag)
custom-made
NLRP9B
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Target
- Nlrp9b (NLRP9B) (NLR Family, Pyrin Domain Containing 9B (NLRP9B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-1003
- Origin
- Mouse
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Nlrp9b protein is labelled with His tag.
- Purpose
- Predefined custom protein recombinant Nlrp9b Protein expressed in mammalian cells.
- Sequence
- MAGSSGYGLL KLLQKLSDEE FQRFKELLRE EPEKFKLKPI SWTKIENSSK ESLVTLLNTH YPGQAWNMML SLFLQVNRED LSIMAQKKKR HKQTKYKKFM KTTFERIWTL ETNTHIPDRN YHLIVEVQYK ALQEIFDSES EPVTAIVAGT TGEGKTTFLR KAMLDWASGV LLQNRFQYVF FFSVFSLNNT TELSLAELIS STLPESSETV DDILSDPKRI LFILDGFDYL KFDLELRTNL CNDWRKRLPT QIVLSSLLQK IMLPGCSLLL ELGQISVPKI RHLLKYPRVI TMQGFSERSV EFYCMSFFDN QRGIEVAENL RNNEVLHLCS NPYLCWMFCS CLKWQFDREE EGYFKAKTDA AFFTNFMVSA FKSTYAHSPS KQNRARLKTL CTLAVEGMWK ELFVFDSEDL RRNGISESDK AVWLKMQFLQ THGNHTVFYH PTLQSYFAAM FYFLKQDKDI CVPVIGSIPQ LLGNMYARGQ TQWLQLGTFL FGLINEQVAA LLQPCFGFIQ PIYVRQEIIC YFKCLGQQEC NEKLERSQTL FSCLRDSQEE RFVRQVVDLL EEITVDISSS DVLSVTAYAL QKSSKLKKLH LHIQKTVFSE IYCPDHCKTR TSIGKRRNTA EYWKTLCGIF CNLYVLDLDS CQFNKRAIQD LCNSMSPTPT VPLTAFKLQS LSCSFMADFG DGSLFHTLLQ LPHLKYLNLY GTYLSMDVTE KLCAALRCSA CRVEELLLGK CGISSKACGI IAISLINSKV KHLSLVENPL KNKGVMSLCE MLKDPSCVLQ SLMLSYCCLT FIACGHLYEA LLSNKHLSLL DLGSNFLEDT GVNLLCEALK DPNCTLKELW LPGCFLTSQC CEEISAVLIC NRNLKTLKLG NNNIQDTGVR QLCEALSHPN CNLECLGLDL CEFTSDCCKD LALALTTCKT LNSLNLDWKT LDHSGLVVLC EALNHKRCNL KMLGLDKSAF SEESQTLLQD VEKKNNNLNI LHHPWFEAER NKRGTRLVWN SRN Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
- Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- Characteristics
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - Purity
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- Grade
- custom-made
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- Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The buffer composition is at the discretion of the manufacturer.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C.
- Expiry Date
- 12 months
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- Target
- Nlrp9b (NLRP9B) (NLR Family, Pyrin Domain Containing 9B (NLRP9B))
- Alternative Name
- Nlrp9b
- Background
- NACHT, LRR and PYD domains-containing protein 9B (NALP-delta),FUNCTION: As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. {ECO:0000269|PubMed:28636595}.
- Molecular Weight
- 114.8 kDa
- UniProt
- Q66X22
- AlphaFold
- Q66X22
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