anti-APH1A Antibodies

Protein Summary

This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

Alternative names and synonyms associated with APH1A

• aph-1 homolog A, gamma-secretase subunit (APH1A) antibody
• aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L) antibody
• aph-1 homolog A, gamma secretase subunit (Aph1a) antibody
• anterior pharynx defective 1 homolog A (C. elegans) (APH1A) antibody
• aph1 homolog A, gamma secretase subunit (Aph1a) antibody
• Show all gene names
• acylamino-acid-releasing enzyme-like (LOC100219182) antibody

• 6530402N02Rik antibody
• APH-1 antibody
• APH-1a antibody
• CGI-78 antibody
• RGD1311546 antibody

Protein level used designations for APH1A

anterior pharynx defective 1 homolog A , aph-1alpha , gamma-secretase subunit APH-1A , presenilin-stabilization factor , anterior pharynx defective 1a homolog , N-acylaminoacyl-peptide hydrolase