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Human Monoclonal JAG2 Primary Antibody for IHC (fro), FACS - ABIN2475163
Lheureux, Even-Adin, Askenasi: Current status of antidotal therapies in acute human intoxications. in Acta clinica Belgica. Supplementum 1990
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Human Polyclonal JAG2 Primary Antibody for IHC, WB - ABIN2782165
Passos Gregorio, Gattaz, Tavares, Kieling, Timm, Wang, Berg Rasmussen, Werge, Dias-Neto: Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. in Schizophrenia research 2006
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Human Polyclonal JAG2 Primary Antibody for ICC, IF - ABIN4327861
Ihara, Hirata, Serizawa, Suzuki, Sakitani, Kinoshita, Hayakawa, Nakagawa, Ijichi, Tateishi, Koike: TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota. in Journal of immunology (Baltimore, Md. : 1950) 2016
A deficiency of KLF2 (show KLF2 Antibodies) increased the expression of Notch ligand Jagged2 via hypoxia-inducible factor 1alpha (HIF-1alpha (show HIF1A Antibodies)), which led to Th2 amplification.
silencing prevents Notch2 (show NOTCH2 Antibodies)-driven osteoclast development and bone destruction in multiple myeloma
Although Jag1 (show JAG1 Antibodies) shares a high degree of homology with Jag2 in the ectodomain region, BACE1 (show BACE Antibodies) fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1 (show JAG1 Antibodies).
Reducing Jagged 1 (show JAG1 Antibodies) and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein (show MGP Antibodies) deficiency.
these findings suggest that Jagged2 signaling can affect graft acceptance by upregulation of IL-6 (show IL6 Antibodies) and consequent resistance to Treg-cell suppression.
results demonstrate that maternal P4 levels during midpregnancy can inhibit the expression of Jagged2 and Notch1 (show NOTCH1 Antibodies), which are involved in primordial folliculogenesis, in the mouse fetal ovary
These data suggest that Notch (show NOTCH1 Antibodies) ligands are differentially regulated in DCs: Delta-like (show DLK1 Antibodies) 4 is regulated by T helper cells and by pathogen-derived Th1 (show HAND1 Antibodies) stimuli, whereas Jagged 2 is regulated by Th2 cells and pathogen-derived Th2-promoting stimuli.
novel Jagged2/miR (show MLXIP Antibodies)-200-dependent pathway that mediates lung adenocarcinoma epithelial-to-mesenchymal transition and metastasis
Loss of Jagged2 is associated with craniofacial, limb, and T cell development.
Notch (show NOTCH1 Antibodies) ligands, including Delta-like1 and 3 and Jagged1 (show JAG1 Antibodies) and Jagged2, show distinct expression patterns in the developing and adult brain overlapping that of Notch1 (show NOTCH1 Antibodies)
In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039).
these results show that the Notch (show NOTCH1 Antibodies) signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 (show JAG1 Antibodies) or Jagged 2 on DCs is not required
The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2 (show NOTCH2 Antibodies), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 Antibodies) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 Antibodies) signalling.
Immunohistochemistry showed a reverse correlation between MUC2 (show MUC2 Antibodies) and Notch3 (show NOTCH3 Antibodies) or Jagged1 (show JAG1 Antibodies) (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 (show JAG1 Antibodies) or Hes1 (show HES1 Antibodies)
Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells
Increased expression of JAG2, a target of miR (show MLXIP Antibodies)-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma.
Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH (show NOTCH1 Antibodies) activation.
This study demonistrated that NOTCH (show NOTCH1 Antibodies) ligands JAG1 (show JAG1 Antibodies) and JAG2 as critical pro-survival factors in childhood medulloblastoma.
Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
Results indicate that Jagged-Notch (show NOTCH1 Antibodies) signaling is required for segregation between wt1 (show WT1 Antibodies)-expressing cells and differentiated steroidogenic tissue.
Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
Mice homozygous for a deletion in the Notch (show NOTCH1 Antibodies)-interaction domain of Jag2 presented a variety of severe dental abnormalities.
Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
Jag2-mediated Notch (show NOTCH1 Antibodies) signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
, protein jagged-2-like
, protein jagged-2
, notch ligand