(Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
custom-made
NR1H3
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
NR1H3
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
NR1H3
Origin: Mouse
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
custom-made
NR1H3
Origin: Human
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Tian, Goldstein, Brown: "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. 8182-7, (2016) (PubMed).
Aliases for NR1H3 Proteins
nuclear receptor subfamily 1 group H member 3 (NR1H3) Proteins nuclear receptor subfamily 1 group H member 3 (nr1h3) Proteins nuclear receptor subfamily 1, group H, member 3 (Nr1h3) Proteins nuclear receptor subfamily 1, group H, member 3 (nr1h3) Proteins AU018371 Proteins im:7141239 Proteins LXR Proteins LXR-a Proteins LXR-alpha Proteins LXRA Proteins LXRalpha Proteins NR1H3 Proteins RLD-1 Proteins RLD1 Proteins Unr1 Proteins wu:fd59b01 Proteins zgc:113339 Proteins zgc:158542 Proteins