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anti-Human BAX Antibodies:
anti-Mouse (Murine) BAX Antibodies:
anti-Rat (Rattus) BAX Antibodies:
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Human Polyclonal BAX Primary Antibody for WB - ABIN5518641
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
Show all 106 Pubmed References
Human Polyclonal BAX Primary Antibody for IHC (p), WB - ABIN5518740
Xu, Yu, He, Li, Yu, Yu: Effects of garlicin on apoptosis in rat model of colitis. in World journal of gastroenterology 2005
Show all 69 Pubmed References
Human Polyclonal BAX Primary Antibody for FACS - ABIN5693067
Xiong, Luo, Zhou, Zeng, Yang: In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures. in Chinese medicine 2010
Show all 60 Pubmed References
Human Polyclonal BAX Primary Antibody for FACS, IF (cc) - ABIN725390
Tian, Zhang, Wang, Dai, Shen, Yang, Huang: The protective effect of hyperbaric oxygen and Ginkgo biloba extract on A?25-35-induced oxidative stress and neuronal apoptosis in rats. in Behavioural brain research 2013
Show all 24 Pubmed References
Human Polyclonal BAX Primary Antibody for ELISA, ICC - ABIN6260205
Liu, Zheng, Zhang, Wang, Yang, Bai, Dai: Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells. in Neurochemical research 2017
Show all 11 Pubmed References
Human Polyclonal BAX Primary Antibody for FACS, IHC (p) - ABIN388094
Liu, Newland, Jia: Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. in Biochemical and biophysical research communications 2003
Show all 13 Pubmed References
Human Polyclonal BAX Primary Antibody for IF (p), IHC (p) - ABIN682843
Pereda: [Histochemical study of the distribution of sialomucins in the oviducts and jelly coat of the oocytes of Rana pipiens. Behavior of the different layers of the coat in water]. in Journal of embryology and experimental morphology 1971
Show all 5 Pubmed References
Human Polyclonal BAX Primary Antibody for IP, WB - ABIN222887
Kim, Zhang, Hitomi, Lee, Mukherjee: Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL. in Human molecular genetics 2006
Show all 5 Pubmed References
Human Polyclonal BAX Primary Antibody for IF, ELISA - ABIN1531490
Berger, Quast, Plötz, Kammermeier, Eberle: Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax. in Cell death & disease 2013
Show all 5 Pubmed References
Human Polyclonal BAX Primary Antibody for ICC, ELISA - ABIN1001866
Lockshin, Osborne, Zakeri: Cell death in the third millennium. in Cell death and differentiation 2000
Show all 4 Pubmed References
Bid (show BID Antibodies) and Bax are signal transduction factors in granulosa cells and play proapoptotic roles.
The data demonstrate that severe hypocapnia results in increased Bax expression, DNA fragmentation, and membrane lipid peroxidation in mitochondria of cerebral cortical neurons of newborn piglets, and may result in apoptotic cell death.
BoHV-5 replication apparently modulates BCL-2 (show BCL2 Antibodies) expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
It was concluded that the Fas (show FAS Antibodies)-FasL (show FASL Antibodies) signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (show TDO2 Antibodies) cell lymphoma/leukemia-2 associated X upregulation.
apoptosis-inducing factor (show AIFM1 Antibodies) was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 (show BCL2 Antibodies) protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax, Bcl-2 (show BCL2 Antibodies), caspase-3 (show CASP3 Antibodies) and-7 cannot be used as a reliable apoptosis detection method.
The effect of culture conditions on expression of heat shock protein 70 (show HSP70 Antibodies) and Bax protein in bovine blastocysts is reported.
xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis.
These results suggest a role for mitochondrial p53 (show TP53 Antibodies) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2 (show BCL2 Antibodies).
Pro-apoptotic protein Bax is main effector of mitochondrial permeabilization during apoptosis. Data suggest Bax N-terminal acetylation by mouse NatB (or yeast Naa20p) is involved in mitochondrial targeting of Bax. These studies used recombinant human Bax expressed in yeast cells plus cultured embryonic cells from knockout, transgenic, and chimeric mice. (NatB and Naa20p = N-terminal acetyltransferases)
This result suggests that p53 (show TP53 Antibodies) has an important role in hemangioma endothelial cell (HemEC) apoptosis. The results of the present study additionally suggest that the propranololinduced HemEC apoptosis pathway is a mitochondrial apoptosis pathway and is regulated by p53BAX signaling.
The results of the present study revealed that the combination of P. gingivalis and H1N1 infection in lung epithelial cells may promote the production of inflammatory cytokines and increase NO production, leading to increased levels of apoptosis in lung epithelial cells via the Bcl2 (show BCL2 Antibodies)/Bax/caspase3 signaling pathway.
The proapoptotic BCL-2 (show BCL2 Antibodies) proteins BAX and BAK (show BAK1 Antibodies) can commit a cell to its programmed death by permeabilizing the outer mitochondrial membrane and subsequent initiation of the caspase (show CASP3 Antibodies) cascade. (Review)
Bax activator BTC (show BTC Antibodies)-8 inhibited glioblastoma (GBM) cell proliferation, arrested the cell cycle, and induced apoptosis through the induction of mitochondrial membrane permeabilization. Most importantly, BTC (show BTC Antibodies)-8 blocked proliferation and self-renewal of glioma stem cells (GSC (show GSC Antibodies)) and induced their apoptosis. BTC (show BTC Antibodies)-8 was demonstrated to sensitize both GBM cells and GSCs to the alkylating agent Temozolomide.
BAX nuclear localization was associated in vivo with the remodelling of lung parenchyma during development, tumorigenesis as well as fibrosis compared to control adult human lungs
There is no significant association between BAX gene polymorphism and cancer susceptibility, but it probably contributes to increased adverse prognosis to cancer.
These results suggest that chlorogenic acid (CGA (show CGA Antibodies))suppresses hLECs apoptosis and prevents lens opacity (show MIP Antibodies) induced by H2O2 via Bax/Bcl2 (show BCL2 Antibodies) signaling pathway. CGA (show CGA Antibodies) may provide effective defenses against oxidative stress and, thus, has potential as treatment for a variety of diseases in clinical practice.
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 (show BCL2 Antibodies) and p53 (show TP53 Antibodies)/Bax activation.
helix alpha9 assists Bax activation via the dimer heterogeneity and interactions with specific MOM lipids, which eventually facilitate proteolipidic pore formation in apoptosis regulation
It was shown that double knockout of Bax and Bak (show BAK1 Antibodies) from proximal tubules attenuated renal tubular cell apoptosis and suppressed renal interstitial fibrosis in UUO.
Study reports the proximal alpha1-alpha2 loop as a second activation site in Bak (show BAK1 Antibodies) and in mitochondrial Bax.
T-2 toxin appears to activate specific intracellular death-related pathways leading to Bax-dependent caspase-3 (show CASP3 Antibodies) activation and the induction of apoptosis in Leydig cells.
The data revealed that autophagy is an important regulator of osteoblastic apoptosis through its interaction with Bax/Bcl2 (show BCL2 Antibodies), and maintains the osteoblastic function of MC3T3E1 cells following GC exposure. In addition, these results indicated that the suppression of autophagy in OBs (show LEP Antibodies) under chronic GC therapy may increase the prevalence of GCinduced osteoporosis and fragility fractures.
Here the authors show that mouse embryonic fibroblasts deficient in Bax/Bak1 (show BAK1 Antibodies) are resistant to the third major form of cell death associated with autophagy through a mechanism involving lysosome permeability.
although all CR subtypes undergo cell death, septum, but not hem, CRs (show CARS Antibodies) die in a Bax-dependent manner. Bax-inactivated rescued septum-CRs (show CARS Antibodies) maintain immature electrophysiological properties
An autoinhibited dimeric form of BAX regulates the cytosolic BAX activation pathway.
Postnatal synaptic rearrangement needed for acquisition of skilled behaviors requires the activity-dependent, non-apoptotic Bax/Bak (show BAK1 Antibodies)-caspase (show CASP3 Antibodies) signaling cascade. Adult Bax/Bak (show BAK1 Antibodies) mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors.
Study found that emphysema occurred in ku70(-/-) mice at the age of three-months old, and that Bax deficiency was able to suppress it. These results suggest that Bax-mediated apoptosis induces emphysema in ku70(-/-) mice.
The polyglutamine embedded in the ER membrane was observed at the same time as Bax insertion. These results demonstrated that the ER membrane may be a target of polyglutamine, which triggers cell death through Bax.
The content of Bax protein in the cardiomyocyte cytoplasm decreased, thus indicating that the mitochondrial pathway was not involved in the realization of the apoptotic program in a model of ventricular overload.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax and decreasing expression of bcl2 (show BCL2 Antibodies).
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 (show BCL2 Antibodies) and increased expression of Bax.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2-associated X protein (BAX) transcripts and protein depending on luteal stage.
bcl-2 (show BCL2 Antibodies) and bax were expressed strongly in denervated guinea-pig facial muscle. [bcl-2 (show BCL2 Antibodies); bax]
goat oocytes based on G6PDH (show G6PD Antibodies)-activity through the BCB test improves their developmental competence, increases intracellular GSH content, and affects the expression of the apoptosis-related genes9 Bax and Bcl-2 (show BCL2 Antibodies) ).
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
BCL2-associated X protein
, BCL2-associated protein
, apoptosis regulator BAX
, bax zeta
, BCL2-associated X protein omega
, BCL2-associated X protein transcript variant delta2
, bcl-2-like protein 4