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anti-Mouse (Murine) PAG1 Antibodies:
anti-Rat (Rattus) PAG1 Antibodies:
anti-Human PAG1 Antibodies:
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Human Monoclonal PAG1 Primary Antibody for FACS, IHC (p) - ABIN94272
Yerly, Ding, Tauzin, van Echten-Deckert, Borisch, Hoessli: The sphingolipid-rich rafts of ALK+ lymphomas downregulate the Lyn-Cbp/PAG signalosome. in European journal of haematology 2010
Show all 6 Pubmed References
Human Monoclonal PAG1 Primary Antibody for IHC (p), IP - ABIN94270
Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. in Blood 2003
Show all 5 Pubmed References
Cow (Bovine) Monoclonal PAG1 Primary Antibody for IHC (p), IP - ABIN269119
Yamashita, Chattopadhyay, Fensterl, Zhang, Sen: A TRIF-independent branch of TLR3 signaling. in Journal of immunology (Baltimore, Md. : 1950) 2012
our findings illustrate that Cbp (show CREBBP Antibodies) is an important regulator of Csk (show CSK Antibodies) recruitment to the SFK Lyn (show LYN Antibodies) in Eporesponsive erythroid cells.
This study demonstrated that cbp (show CREBBP Antibodies) increase in skeletal muscle in muscle atrophy.
PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
PAG (show PRDX1 Antibodies) can function as both a positive and a negative regulator of mast cell signaling, depending upon the signaling pathway involved. PAG (show PRDX1 Antibodies) is a positive regulator of passive systemic anaphylaxis.
Data show that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain.
Cbp plays a role in adult hematopoietic stem cell homeostasis.
Cbp (show CREBBP Antibodies) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (show MAPK1 Antibodies)/PI3K pathways in a subset of cancer cells.
expression of Cbp is downregulated during osteoclast differentiation, consequently inhibiting recruitment of Csk to lipid rafts and keeping c-Src activity high in osteoclasts. findings provide a novel paradigm that controls c-Src activity in osteoclasts.
CBP (show CREBBP Antibodies) plays a role in transiently anchoring Thy-1 (show THY1 Antibodies) to the cytoskeleton.
Low PAG1 expression is associated neuroblastoma (show ARHGEF16 Antibodies).
Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src (show SRC Antibodies) and AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathways.
Up-regulated expression of CBP (show CREBBP Antibodies) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
No association Pag1 mutation with patient with Schizophrenia.
The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (show BLNK Antibodies) and have a pro-inflammatory effect.
CBP (show CREBBP Antibodies) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (show SRC Antibodies).
The inhibitory function of novobiocin in disrupting the HIF1alpha (show HIF1A Antibodies)/p300 (show EP300 Antibodies) complex might be important in tumor cell growth.
siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.
expression of CBP (show CREBBP Antibodies) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.
An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (show EPHB2 Antibodies), as well as the cyclin D1 (show CCND1 Antibodies) expression, leading to an inhibition of the proliferation ability of tumor cells.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
, phosphoprotein transmembrane adaptor 1
, phosphoprotein-associated with GEMs
, transmembrane phosphoprotein Cbp
, Csk binding protein
, csk-binding protein
, transmembrane adapter protein PAG
, transmembrane adaptor protein PAG
, phosphoprotein associated with glycosphingolipid microdomains 1
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1-like