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anti-Human PDCD6IP Antibodies:
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Human Polyclonal PDCD6IP Primary Antibody for WB - ABIN1881644
Inuzuka, Suzuki, Kawasaki, Shibata, Wakatsuki, Maki: Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition. in BMC structural biology 2010
Show all 4 Pubmed References
Human Polyclonal PDCD6IP Primary Antibody for IF, IHC - ABIN347079
Mahul-Mellier, Hemming, Blot, Fraboulet, Sadoul: Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Show all 6 Pubmed References
Human Monoclonal PDCD6IP Primary Antibody for IF, IHC (p) - ABIN2477348
Bechmann, Weiss: Regulation of the proton/electron stoichiometry of mitochondrial ubiquinol:cytochrome c reductase by the membrane potential. in European journal of biochemistry / FEBS 1991
Show all 4 Pubmed References
Human Polyclonal PDCD6IP Primary Antibody for IF, WB - ABIN523392
Kowal, Arras, Colombo, Jouve, Morath, Primdal-Bengtson, Dingli, Loew, Tkach, Théry: Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. in Proceedings of the National Academy of Sciences of the United States of America 2016
Human Monoclonal PDCD6IP Primary Antibody for ICC, IF - ABIN260230
Haga, Yan, Takahashi, Matsuda, Patel: Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice. in Stem cells translational medicine 2017
our results identify the CD63 (show CD63 Antibodies)-syntenin-1 (show SDCBP Antibodies)-ALIX complex as a key regulatory component in post-endocytic HPV trafficking.
Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration.
Revealed the transition of diffuse ALIX protein signals into a multivesicular body-like pattern during adenoma-carcinoma sequence in colorectal neoplasms.
STAT3 (show STAT3 Antibodies) bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 (show WDR1 Antibodies) gene, and its activation induced WDR1 (show WDR1 Antibodies) overexpression in breast cancer cells.
MRTF-A (show MKL1 Antibodies)-miR (show MLXIP Antibodies)-206-WDR1 (show WDR1 Antibodies) form feedback loop to regulate breast cancer cell migration.
Alix plays an important role in the proliferation of glioma cells and overexpression in gliomas predicts poor survival.
homozygous missense L153F/L293F mutation in the actin regulatory gene WDR1 (show WDR1 Antibodies) causes a new autoinflammatory disease in humans, with periodic fevers, immunodeficiency, and intermittent thrombocytopenia (PFIT).
These data suggest that WDR1 (show WDR1 Antibodies) plays an important role in suppressing platelet activity, where it alters the actin cytoskeleton dynamics, and downregulation of WDR1 (show WDR1 Antibodies) may contribute to the platelet-mediated pathogenesis of cardiovascular disease.
Mutations in WDR1 (show WDR1 Antibodies) affect neutrophil morphology, motility, and function, causing a novel primary immunodeficiency
ALIX regulates P2Y1 (show P2RY1 Antibodies) degradation.
By interacting with F-actin, the Par (show AFG3L2 Antibodies) complex and ZO-1 (show TJP1 Antibodies), Alix ensures the formation and maintenance of the apically restricted actomyosin-tight junction complex.
farnesylation of K-Ras (show HRAS Antibodies) was required for its packaging within extracellular nanovesicles, yet expressing a K-Ras (show HRAS Antibodies) farnesylation mutant did not decrease the number of nanovesicles or the amount of Alix protein released per cell.
ATG12 (show ATG12 Antibodies)-ATG3 (show ATG3 Antibodies) interacts with Alix to promote basal autophagic flux and late endosome function.
We have provided evidence that a promigratory function of galectin-3 (show LGALS3 Antibodies) may be mediated through interaction with its binding partner Alix.
Identify key role for syndecan (show SDC1 Antibodies)-syntenin (show SDCBP Antibodies)-ALIX in membrane transport and signalling processes.
the Ozz-E3 ligase regulates Alix at sites where the actin cytoskeleton undergoes remodeling.
Alix is a crucial mediator of Ca(2 (show CA2 Antibodies)+) induced caspase 9 (show CASP9 Antibodies) activation.
Biochemical characterization of two analogues of the apoptosis-linked gene 2 protein (show PDCD6 Antibodies) in Dictyostelium discoideum and interaction with murine Alix.
overexpression of Alix-CT leads to cytoplasmic vacuolization into tubulo-vesicular structures
We conclude that ALIX and ESCRT-III coordinately control abscission in Drosophila fGSCs and that their complex formation is required for accurate abscission timing in GSCs in vivo.
These findings establish that Xp95/Alix is phosphorylated within the proline-rich domain during M-phase induction, and indicate that the phosphorylation may both positively and negatively modulate their interaction with partner proteins.
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
ALG-2 interacting protein 1
, ALG-2-interacting protein X
, PDCD6-interacting protein
, apoptosis-linked gene 2-interacting protein X
, dopamine receptor interacting protein 4
, programmed cell death 6-interacting protein
, WD repeat-containing protein 1
, actin-interacting protein 1
, ALG-2-interacting protein 1
, Alg2-interacting protein 1
, Alg2-interacting protein X
, E2f1-inducible protein
, ALG-2 interacting protein X
, programmed cell death 6 interacting protein
, Programmed cell death 6 interacting protein
, putative signal tranduction protein Xp95
, signal transduction protein Xp95