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Recombinant ALIX antibody

PDCD6IP Reactivity: Human WB, ELISA, FACS Host: Rabbit Monoclonal 7E9 unconjugated Recombinant Antibody
Catalog No. ABIN7127335
  • Target See all ALIX (PDCD6IP) Antibodies
    ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 70
    • 32
    • 31
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 59
    • 11
    • 2
    Rabbit
    Clonality
    • 55
    • 16
    Monoclonal
    Conjugate
    • 32
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This ALIX antibody is un-conjugated
    Application
    • 46
    • 26
    • 26
    • 22
    • 12
    • 11
    • 10
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    Cross-Reactivity
    Human, Rat
    Purification
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human ALIX
    Clone
    7E9
    Isotype
    IgG
    Top Product
    Discover our top product PDCD6IP Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
    Alternative Name
    PDCD6IP (PDCD6IP Products)
    Synonyms
    DDBDRAFT_0167145 antibody, DDBDRAFT_0185177 antibody, DDB_0167145 antibody, DDB_0185177 antibody, AIP1 antibody, ALIX antibody, DRIP4 antibody, HP95 antibody, AI480591 antibody, AW544830 antibody, Aip1 antibody, Alix antibody, C76364 antibody, Eig2 antibody, mKIAA1375 antibody, CG12876 antibody, DAIP1 antibody, Dmel\\CG12876 antibody, GB11744 antibody, RGD1561176 antibody, zgc:63638 antibody, wu:fb70d03 antibody, wu:fy65h02 antibody, PDCD6IP antibody, aip1 antibody, alix antibody, hp95 antibody, drip4 antibody, ALG-2 interacting protein X antibody, programmed cell death 6 interacting protein antibody, programmed cell death 6-interacting protein antibody, Programmed cell death 6 interacting protein antibody, programmed cell death 6 interacting protein L homeolog antibody, alxA antibody, PDCD6IP antibody, Pdcd6ip antibody, ALiX antibody, LOC412662 antibody, pdcd6ip antibody, Bm1_48390 antibody, pdcd6ip.L antibody
    Background

    Background: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).

    Aliases: Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95), PDCD6IP, AIP1 ALIX KIAA1375

    UniProt
    Q8WUM4
    Pathways
    p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation
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