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anti-Rat (Rattus) TNFRSF10B Antibodies:
anti-Human TNFRSF10B Antibodies:
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Human Polyclonal TNFRSF10B Primary Antibody for FACS, ICC - ABIN4361766
Basile, Zacny, Münger et al.: The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the ... in The Journal of biological chemistry 2001
Show all 37 Pubmed References
Human Polyclonal TNFRSF10B Primary Antibody for FACS, ICC - ABIN4361767
Cuello, Ettenberg, Clark, Keane, Posner, Nau, Dennis, Lipkowitz et al.: Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that ... in Cancer research 2001
Show all 18 Pubmed References
Human Monoclonal TNFRSF10B Primary Antibody for CyTOF, FACS - ABIN4900599
Barbarotto, Corallini, Rimondi, Fadda, Mischiati, Grill, Vaccarezza, Celeghini: Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells. in Journal of cellular biochemistry 2008
Show all 16 Pubmed References
Human Monoclonal TNFRSF10B Primary Antibody for FACS - ABIN4898056
Peppa, Gill, Reynolds, Easom, Pallett, Schurich, Micco, Nebbia, Singh, Adams, Kennedy, Maini: Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. in The Journal of experimental medicine 2013
Show all 13 Pubmed References
Human Monoclonal TNFRSF10B Primary Antibody for FACS, Func - ABIN1169245
Sprick, Rieser, Stahl, Grosse-Wilde, Weigand, Walczak: Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. in The EMBO journal 2002
Show all 6 Pubmed References
Human Monoclonal TNFRSF10B Primary Antibody for - ABIN1383912
Sato, Niessner, Kopecky, Frye, Goronzy, Weyand: TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. in The Journal of experimental medicine 2006
Show all 3 Pubmed References
Mouse (Murine) Polyclonal TNFRSF10B Primary Antibody for CyTOF, FACS - ABIN4900408
Park, Wu, Choi, Najafi, Emami, Safa: P-glycoprotein enhances TRAIL-triggered apoptosis in multidrug resistant cancer cells by interacting with the death receptor DR5. in Biochemical pharmacology 2006
Show all 3 Pubmed References
Human Polyclonal TNFRSF10B Primary Antibody for IHC (p), WB - ABIN3044205
Liu, Zuo, Wang, Chen, Yang, Wang, Zhu: miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT. in Oncotarget 2014
Show all 2 Pubmed References
Human Monoclonal TNFRSF10B Primary Antibody for FACS - ABIN1383914
Mérino, Lalaoui, Morizot, Schneider, Solary, Micheau: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. in Molecular and cellular biology 2006
Show all 2 Pubmed References
Human Monoclonal TNFRSF10B Primary Antibody for IP - ABIN1383915
Vermot-Desroches, Sergent, Bonnin, Wijdenes: Characterization of monoclonal antibodies directed against trail or trail receptors. in Cellular immunology 2005
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GDF-15 (show GDF15 Antibodies) and TRAIL-R2 were the most powerful Proximity Extension Assay chip biomarkers in predicting long-term all-cause mortality in patients with acute myocardial infarction.
In contrast to apoptosis, necroptotic signaling was activated similarly by both DR4 (show HLADRB4 Antibodies)- or DR5-specific ligands..Our study provides the first systematic insight into DR4 (show HLADRB4 Antibodies)-/DR5-specific signaling in colorectal and pancreatic cancer cells
These data suggest that the humanized anti-TRAIL-R2 monoclonal antibody or the second generation of the antibody may have an important clinical usage for cancer immunotherapy
We found that pharmacological application of Golgi stress leads to induction of death receptors (DRs (show PNN Antibodies)) 4 and 5. DR4 (show HLADRB4 Antibodies) appears to be primarily responsible for the initiation of cell death downstream of Golgi stress, whereas DR5 seems to be more important for cell death triggered by endoplasmic reticulum (ER) stress in specific cancer cell lines
Knocking-down of TRAIL-DR5 gene in breast cancer cells MCF-7 markedly decreased the mRNA and protein levels of the autophagy-related factors.
Antineoplasic agents etoposide (ET) and doxorubicin enhance the expression of Death receptor 5 (DR5) in triple-negative breast cancer (TNBC) cells. DR5 residue SerB68 is important in mediating the receptor-drug interaction. Apoptosis and DR5 expression are induced in xenograft mice and in TNBC patient-derived metastatic cells after treatment with TNF-Related Apoptosis-Inducing Ligand (TRAIL (show TNFSF10 Antibodies)) and ET.
DR5, BIRC5/Survivin, XIAP, c-IAP1 and c-IAP2 mRNA expression are significantly deregulated in CRC and could provide a panel of markers with significant discriminatory value between CRC and normal colorectal tissue
DR5 has a dual role in death and survival signaling, which results in TRAIL resistance in cancer cells.
The B-Raf (show SNRPE Antibodies) inhibitor PLX4032 induces DR5 upregulation exclusively in Ras-mutant cancer cells; this effect is dependent on Ras/c-Raf (show RAF1 Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling activation.
ONC201 has potent antiproliferative and proapoptotic effects in a broad range of breast cancer subtypes, through TRAIL-dependent and TRAIL-independent mechanisms.The small-molecule ONC201 induces expression of TRAIL and its receptor DR5. ONC201 has entered clinical trials in advanced cancers. Here, we show that ONC201 is efficacious against both triple-negative breast cancers (TNBC) and non-TNBC cells
Death receptor5 pathway and mitochondrial pathway, which are likely mediated by HIF-1alpha (show HIF1A Antibodies), contribute to hypoxia-induced spermatocyte apoptosis.
Authors demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL (show TNFSF10 Antibodies)) and its signaling death receptor 5 (DR5) in the murine inner ear.
Malignant transformation in the endometrium is related to reduction of membrane DR4 (show HLADRB4 Antibodies) and DR5 expression.
TRAIL expression by osteoclast-like cells is increased in the presence of RANKL (show TNFSF11 Antibodies) and after scraping; DcR2 (show TNFRSF10D Antibodies) expression peaks at 24 hours, and and decreases at 5 days; DR5 expression peaks at 5 days
Induction of death receptor 5 expression in tumor vasculature by perifosine restores the vascular disruption activity of TRAIL-expressing CD34 (show CD34 Antibodies)(+) cells.
TRAIL-DR5 interaction promoted malignant behaviors of B16F10 cells.
results suggest that the transmembrane domains together with their adjacent stalk regions can play a major role in control of death receptor activation thereby contributing to cell type specific differences in TRAILR1 and TRAILR2 signaling
DR5 is selectively expressed by neuroprogenitor cells and newborn neurons.
Results suggest that excessive iodine could induce TRAIL and DR5 abnormal expression in thyroid. TRAIL band with DR5 to promote follicular cells apoptosis thus mediate thyroid destruction in EAT.
NK cells inhibit dendritic cell cross-priming, but not direct priming, in a TRAIL/DR5-dependent manner.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
tumor necrosis factor receptor superfamily, member 10b
, death receptor-M2
, death receptor-M1
, Fas-like protein
, TNF-related apoptosis-inducing ligand receptor 2
, apoptosis inducing protein TRICK2A/2B
, apoptosis inducing receptor TRAIL-R2
, cytotoxic TRAIL receptor-2
, death domain containing receptor for TRAIL/Apo-2L
, death receptor 5
, p53-regulated DNA damage-inducible cell death receptor(killer)
, tumor necrosis factor receptor superfamily member 10B
, tumor necrosis factor receptor-like protein ZTNFR9
, KILLER/DR5 TRAIL death-inducing receptor