IL-36beta (human) Matched Pair Detection Set
Quick Overview for IL-36beta (human) Matched Pair Detection Set (ABIN6253509)
Target
Reactivity
Host
Application
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Detection Method
- Colorimetric
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Method Type
- Sandwich ELISA
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Detection Range
- 15.6 pg/mL - 1000 pg/mL
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Minimum Detection Limit
- 15.6 pg/mL
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Purpose
- IL-36beta (human) Matched Pair Detection Set
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Sensitivity
- 10 pg/mL
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Characteristics
- Matched Pair Detection Set. Detects human IL-36beta in cell culture supernatant. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 1000 pg/mL. Sensitivity: 10 pg/mL. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
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Components
- 1 vial standard protein (100ng) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (60μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
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Restrictions
- For Research Use only
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Concentration
- Lot specific
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Handling Advice
- Avoid freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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- FIL1h (Interleukin 1 eta (FIL1h))
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Alternative Name
- IL-36beta
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Background
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Alternate Names/Synonyms: Interleukin-36beta Interleukin-1 Family Member 8, IL-1F8
Product Description: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Target
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