Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (C-Term) Peptide
LDLRAP1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN1541170
Quick Overview for Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (C-Term) Peptide (ABIN1541170)
Target
LDLRAP1
(Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- APLSTVSANT NNVDETPRPQ VLGNNSVVWE LDDGLDEAFS RLAQSRTNPQ
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Ldlrap1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
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Background
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Ldlrap1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). It may be required for LDL binding and internalization but not for receptor clustering in coated pits. It may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. Ldlrap1 may also be involved in the internalization of other LDLR family members. Ldlrap1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
Alias Symbols: AA691260, ARH2, Arh, Arh1, FHCB1, FHCB2
Protein Size: 264 -
Molecular Weight
- 29 kDa
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Gene ID
- 100017
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NCBI Accession
- NM_145554, NP_663529
Target
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