GRB2-Related Adaptor Protein (GRAP) (N-Term) Peptide
GRAP
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2184413
Quick Overview for GRB2-Related Adaptor Protein (GRAP) (N-Term) Peptide (ABIN2184413)
Target
GRAP
(GRB2-Related Adaptor Protein (GRAP))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- SDELAFNKGD TLKILNMEDD QNWYKAELRG VEGFIPKNYI RVKPHPWYSG
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Characteristics
- This is a synthetic peptide designed for use in combination with antiGRAP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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GRB2-Related Adaptor Protein (GRAP) peptide
GRAP Reactivity: Human, Rat, Cow, Mouse Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at 20C. Avoid repeat freezethaw cycles.
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- GRAP (GRB2-Related Adaptor Protein (GRAP))
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Background
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This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligandactivated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCRABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its Nterminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Alias Symbols: -
Protein Size: 217 -
Molecular Weight
- 25 kDa
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Gene ID
- 10750
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NCBI Accession
- NM_006613, NP_006604
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UniProt
- Q13588
Target
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