Fibroblast Growth Factor Receptor 1 (FGFR1) (N-Term) Peptide
FGFR1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all FGFR1 products
- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
- Protein Region
- N-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNRRPV APYWTSPEKM
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Fgfr1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Fibroblast Growth Factor Receptor 1 (FGFR1) peptide
FGFR1 Reactivity: Human, Cow, Dog Host: Synthetic BP, Imm
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
- Synonyms
- FGFR Peptide, fgfr Peptide, X1FGFR Peptide, XFGFR-1 Peptide, XFGFRA2 Peptide, bfgfr Peptide, cek Peptide, fgfr1 Peptide, flg Peptide, flt-2 Peptide, flt2 Peptide, kal2 Peptide, ogd Peptide, xfgfr1 Peptide, CG7223 Peptide, CT22273 Peptide, CT39172 Peptide, DFGF-R1 Peptide, DFGF-R2 Peptide, DFR-1 Peptide, DFR1 Peptide, DFR1/DFGF-R2 Peptide, DPR3 Peptide, DTRK(FR1) Peptide, Dfr-1 Peptide, Dfr1 Peptide, DmHD-38 Peptide, Dmel\\CG7223 Peptide, Dtk1 Peptide, EMS2 Peptide, FGF-R2 Peptide, FGFR2 Peptide, FR1 Peptide, Fr1 Peptide, HD-38 Peptide, HTL/FGFR1 Peptide, Htl Peptide, Tk1 Peptide, dtk1 Peptide, i100 Peptide, i150 Peptide, i79 Peptide, j372 Peptide, cd331 Peptide, fgfbr Peptide, fgfr-1 Peptide, hbgfr Peptide, n-sam Peptide, ach Peptide, cd333 Peptide, cek2 Peptide, fgfr-3 Peptide, hsfgfr3ex Peptide, jtk4 Peptide, BFGFR Peptide, CD331 Peptide, CEK Peptide, FGFBR Peptide, FGFR-1 Peptide, FLG Peptide, FLT-2 Peptide, FLT2 Peptide, HBGFR Peptide, HH2 Peptide, KAL2 Peptide, N-SAM Peptide, OGD Peptide, bFGF-R-1 Peptide, AW208770 Peptide, Eask Peptide, Fgfr-1 Peptide, Flt-2 Peptide, Hspy Peptide, FLG-1 Peptide, FGFRI Peptide, x1fgfr Peptide, cb231 Peptide, sb:cb231 Peptide, fibroblast growth factor receptor Peptide, fibroblast growth factor receptor 1 S homeolog Peptide, basic fibroblast growth factor receptor 1 Peptide, heartless Peptide, fibroblast growth factor receptor 1 Peptide, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog Peptide, Fibroblast growth factor receptor 1 Peptide, fibroblast growth factor receptor 1 L homeolog Peptide, fibroblast growth factor receptor 1a Peptide, FGFR Peptide, fgfr Peptide, fgfr1.S Peptide, CpipJ_CPIJ005849 Peptide, htl Peptide, fgfr1 Peptide, fgfr3.L Peptide, FGFR1 Peptide, Fgfr1 Peptide, fgfr1.L Peptide, fgfr1a Peptide
- Background
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Fgfr1 is a Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Fgfr1 phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. It promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, Fgfr1 enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation
Alias Symbols: AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy
Protein Size: 822 - Molecular Weight
- 92 kDa
- Gene ID
- 14182
- NCBI Accession
- NM_010206, NP_034336
- UniProt
- P16092
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