Prion Protein (PRNP) (Middle Region) Peptide
PRNP
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all PRNP products
- PRNP (Prion Protein (PRNP))
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Prnp Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PRNP (Prion Protein (PRNP))
- Synonyms
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ASCR Peptide, AltPrP Peptide, CD230 Peptide, CJD Peptide, GSS Peptide, KURU Peptide, PRIP Peptide, PrP Peptide, PrP27-30 Peptide, PrP33-35C Peptide, PrPc Peptide, p27-30 Peptide, Prn Peptide, Prn-p Peptide, prp Peptide, cjd Peptide, prion Peptide, prp(c) Peptide, MGC84114 Peptide, PRP Peptide, PRPC Peptide, Prp Peptide, SIP Peptide, PRNP Peptide, AA960666 Peptide, AI325101 Peptide, PrP
Peptide, PrPC Peptide, PrPSc Peptide, Prn-i Peptide, Sinc Peptide, prP27-30 Peptide, prP33-35C Peptide, PrP-1 Peptide, PrP1 Peptide, prnprs1 Peptide, stPrP-1 Peptide, zgc:123004 Peptide, prion protein Peptide, prion protein S homeolog Peptide, prion protein b Peptide, PRNP Peptide, Prnp Peptide, prnp.S Peptide, prnpb Peptide - Background
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Prnp may play a role in neuronal development and synaptic plasticity, may be required for neuronal myelin sheath maintenance and may play a role in iron uptake and iron homeostasis. Prnp is a soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. It also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Alias Symbols: AA960666, AI325101, CD230, PrP, PrP, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C
Protein Size: 254 - Molecular Weight
- 28 kDa
- Gene ID
- 19122
- NCBI Accession
- NM_011170, NP_035300
- UniProt
- P04925
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