Transcription Factor EB (TFEB) (C-Term) Peptide
TFEB
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511586
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Transcription Factor EB (TFEB) (C-Term) Peptide (ABIN5511586)
Target
TFEB
(Transcription Factor EB (TFEB))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- PALPPQAPLP LPTQPPSPFH HLDFSHSLSF GGREDEGPPG YPEPLAPGHG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TFEB Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TFEB (Transcription Factor EB (TFEB))
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Background
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TFEB is a transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. TFEB acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. TFEB specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. TFEB plays a role in the signal transduction processes required for normal vascularization of the placenta.
Alias Symbols: TFEB, BHLHE35,
Protein Size: 476 -
Gene ID
- 7942
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NCBI Accession
- XP_005249469
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UniProt
- P19484
Target
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