2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (C-Term) Peptide
OAS1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all OAS1 products
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AESNSADDET DDPRRYQKYG YIGTHEYPHF SHRPSTLQAA STPQAEEDWT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-OAS1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
- Synonyms
- OAS1 Peptide, IFI-4 Peptide, OIAS Peptide, OIASI Peptide, L3 Peptide, Pp2a2 Peptide, 2',5'-oligoadenylate synthetase 1 Peptide, 2'-5'-oligoadenylate synthetase 1 Peptide, 2'-5' oligoadenylate synthetase 1A Peptide, protein phosphatase 2 catalytic subunit beta Peptide, OAS1 Peptide, Oas1a Peptide, Ppp2cb Peptide, Oas1 Peptide
- Background
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This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: OAS1, OIAS,
Protein Size: 400 - Gene ID
- 4938
- NCBI Accession
- NP_058132
- UniProt
- P00973
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