Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF) (N-Term) Peptide
LITAF
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all LITAF products
- LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PSYEETVAVN SYYPTPPAPM PGPTTGLVTG PDGKGMNPPS YYTQPAPIPN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-LITAF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))
- Synonyms
- PIG7 Peptide, SIMPLE Peptide, TP53I7 Peptide, EET-1 Peptide, Pig7 Peptide, TNF-alpha Peptide, 3222402J11Rik Peptide, C85531 Peptide, N4WBP3 Peptide, TBX1 Peptide, lipopolysaccharide induced TNF factor Peptide, lipopolysaccharide-induced TNF factor Peptide, LPS-induced TN factor Peptide, LITAF Peptide, Litaf Peptide
- Background
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Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: LITAF,PIG7,SIMPLE,
Protein Size: 228 - Gene ID
- 9516
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