DNA-Damage-Inducible Transcript 4 (DDIT4) (N-Term) Peptide
DDIT4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DDIT4 products
- DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LWDRFSSSST SSSPSSLPRT PTPDRPPRSA WGSATREEGF DRSTSLESSD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- DDIT4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
- Synonyms
- redd1 Peptide, Dig2 Peptide, REDD-1 Peptide, REDD1 Peptide, 5830413E08Rik Peptide, AA415483 Peptide, Rtp801 Peptide, dig2 Peptide, rtp801 Peptide, sb:cb821 Peptide, zgc:64114 Peptide, DNA damage inducible transcript 4 Peptide, DNA-damage-inducible transcript 4 Peptide, DNA damage inducible transcript 4 S homeolog Peptide, ddit4 Peptide, DDIT4 Peptide, Ddit4 Peptide, ddit4.S Peptide
- Background
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Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
Alias Symbols: Dig2, REDD1, REDD-1
Protein Size: 232 - Gene ID
- 54541
- NCBI Accession
- NM_019058, NP_061931
- UniProt
- Q9NX09
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