B-Cell Linker (BLNK) (N-Term) Peptide
BLNK
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all B-Cell Linker (BLNK) products
- B-Cell Linker (BLNK)
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ADEEEQWSDD FDSDYENPDE HSDSEMYVMP AEENADDSYE PPPVEQETRP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- BLNK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- B-Cell Linker (BLNK)
- Synonyms
- BLNK Peptide, blnk Peptide, MGC147045 Peptide, BASH Peptide, Bca Peptide, Ly-57 Peptide, Ly57 Peptide, Lyw-57 Peptide, SLP-65 Peptide, AGM4 Peptide, BLNK-S Peptide, LY57 Peptide, SLP65 Peptide, bca Peptide, B-cell linker Peptide, B cell linker Peptide, BLNK Peptide, blnk Peptide, Blnk Peptide
- Background
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This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
Alias Symbols: bca, AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65
Protein Size: 456 - Gene ID
- 29760
- NCBI Accession
- NM_001114094, NP_001107566
- UniProt
- Q8WV28
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