Kinesin Associated Protein 3 (KIFAP3) Peptide
KIFAP3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513164
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Kinesin Associated Protein 3 (KIFAP3) Peptide (ABIN5513164)
Target
KIFAP3
(Kinesin Associated Protein 3 (KIFAP3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-KAP3 antibody (Catalog #: ARP75056_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KIFAP3 (Kinesin Associated Protein 3 (KIFAP3))
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Background
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CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
Protein Size: 418 -
Molecular Weight
- 45 kDa
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Gene ID
- 5577
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NCBI Accession
- NP_002727
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UniProt
- P31323
Target
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