BR serine/threonine Kinase 2 (BRSK2) (Middle Region) Peptide
BRSK2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all BRSK2 products
- BRSK2 (BR serine/threonine Kinase 2 (BRSK2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EEENQEKMIY FLLLDRKERY PSQEDEDLPP RNEIDPPRKR VDSPMLNRHG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BRSK2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BRSK2 (BR serine/threonine Kinase 2 (BRSK2))
- Synonyms
- C11orf7 Peptide, PEN11B Peptide, SAD1 Peptide, SADA Peptide, STK29 Peptide, BRSK2 Peptide, 4833424K13Rik Peptide, SAD-A Peptide, BR serine/threonine kinase 2 Peptide, BRSK2 Peptide, Brsk2 Peptide
- Background
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BRSK2 is a serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. It phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. It also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. It plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. It plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 is phosphorylated at Thr-174 can inhibit insulin secretion, BRSK2 is phosphorylated at Thr-260 can promote insulin secretion. It regulates reorganization of the actin cytoskeleton. It may play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
Alias Symbols: BRSK2,C11orf7,PEN11B,SADA,STK29,HUSSY-12,
Protein Size: 766 - Gene ID
- 9024
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