Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (Middle Region) Peptide
GEMIN2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SIP1 (GEMIN2) products
- SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QQQQVAQFST VRQNVNKHRS HWKSQQLDSN VTMPKSEDEE GWKKFCLGEK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- SIP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
- Synonyms
- SIP1 Peptide, SIP1-delta Peptide, 1700012N19Rik Peptide, Sip1 Peptide, sip1 Peptide, sip1-delta Peptide, wu:fc52a05 Peptide, zgc:110274 Peptide, gem nuclear organelle associated protein 2 Peptide, gem (nuclear organelle) associated protein 2 Peptide, gem nuclear organelle associated protein 2 S homeolog Peptide, GEMIN2 Peptide, Gemin2 Peptide, gemin2.S Peptide, gemin2 Peptide
- Background
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This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Alias Symbols: SIP1, SIP1-delta
Protein Size: 280 - Gene ID
- 8487
- NCBI Accession
- NM_001009182, NP_001009182
- UniProt
- O14893
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