SH2 Domain Containing 1A (SH2D1A) (Middle Region) Peptide
SH2D1A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513555
Quick Overview for SH2 Domain Containing 1A (SH2D1A) (Middle Region) Peptide (ABIN5513555)
Target
SH2D1A
(SH2 Domain Containing 1A (SH2D1A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- YTYRVSQTET GSWSAETAPG VHKRYFRKIK NLISAFQKPD QGIVIPLQYP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SH2D1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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Background
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SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Protein Size: 125 -
Gene ID
- 4068
Target
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