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SH2 Domain Containing 1A (SH2D1A) (C-Term) Peptide

SH2D1A Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN983683
  • Target See all SH2D1A products
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Protein Region
    C-Term
    Origin
    Human
    Source
    • 7
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-SH2D1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Synonyms
    DSHP Peptide, EBVS Peptide, IMD5 Peptide, LYP Peptide, MTCP1 Peptide, SAP Peptide, SAP/SH2D1A Peptide, XLP Peptide, XLPD Peptide, RGD1562408 Peptide, Gm686 Peptide, SH2D1A Peptide, SH2 domain containing 1A Peptide, SH2D1A Peptide, Sh2d1a Peptide
    Background
    SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

    Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A

    Protein Interaction Partner: CD244,CD84,LY9,SLAMF1,SLAMF1,ARHGEF6,ARHGEF7,CD84,DOK1,FYB,FYN,GRB2,LCK,LY9,SLAMF1,SLAMF6,SLAMF7,CD244,CD84,DOK1,FYN,LY9,SLAMF1,SLAMF6

    Protein Size: 128
    Molecular Weight
    14 kDa
    Gene ID
    4068
    NCBI Accession
    NM_002351, NP_002342
    UniProt
    O60880
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