Mitogen-Activated Protein Kinase 10 (MAPK10) (Middle Region) Peptide
MAPK10
Reactivity: Human
Host: Synthetic
WB
Catalog No. ABIN5518173
$160.46
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100 μg
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Quick Overview for Mitogen-Activated Protein Kinase 10 (MAPK10) (Middle Region) Peptide (ABIN5518173)
Target
MAPK10
(Mitogen-Activated Protein Kinase 10 (MAPK10))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))
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Background
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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Protein Size: 167 -
Gene ID
- 5602
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NCBI Accession
- NM_002753, NP_002744
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UniProt
- P53779
Target
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