Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) (N-Term) Peptide
GAD2
Reactivity: Human
Host: Synthetic
WB
Catalog No. ABIN5518489
Quick Overview for Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) (N-Term) Peptide (ABIN5518489)
Target
GAD65 (GAD2)
(Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- FWSFGSEDGS GDSENPGTAR AWCQVAQKFT GGIGNKLCAL LYGDAEKPAE
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
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Background
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Alias Symbols: GAD65,
Protein Size: 585 -
Gene ID
- 2572
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NCBI Accession
- NM_000818, NP_000809
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UniProt
- Q05329
Target
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