Hemoglobin C Peptide
Quick Overview for Hemoglobin C Peptide (ABIN5624621)
Target
Source
Application
-
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Peptide Type
- Synthetic
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Supplier Product No.
- 000-001-gs7
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Supplier
- Rockland
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Purpose
- HbC Control Peptide
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Characteristics
- HbC Control Peptide, Hemoglobin beta subunit C variant, HbBc, HbC, Sickle Cell Disease (SCD)
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Purification
- Greater than 95% specific peptide
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Purity
- Greater than 95% specific peptide
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-
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Application Notes
- Optional[Flow Cytometry Dilution]: HbC peptide can be used as a control with the HbC antibody. Control peptide should be used at 1.0 μg per 1.0 μL of antiserum in per assay.
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Restrictions
- For Research Use only
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-
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Format
- Lyophilized
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Reconstitution
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Reconstitution Buffer: Restore with deionized water (or equivalent)
Reconstitution Volume: 50μL
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Concentration
- 1.0 mg/mL
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Buffer
-
Buffer: None
Stabilizer: None
Preservative: None -
Preservative
- Without preservative
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store vial at 2-8 °C prior to opening. Aliquot contents and freeze at -20 °C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.
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Expiry Date
- 6 months
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- Hemoglobin C
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Background
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Synonyms: HbC Control Peptide, Hemoglobin beta subunit C variant, HbBc, HbC, Sickle Cell Disease (SCD)
Background: HbC peptide corresponds to the E6K mutant in the amino-terminal portion of hemoglobin beta subunit. Functional hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Less significant than the SCD-E6V, HbC E6K mutation causes a mild hemolytic anemia. HbC peptide is suitable for use as a control with the HbC antibody. This peptide is ideal for investigators involved in Cardiovascular and developmental biology research.
Target
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