MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptide
MSH6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MSH6 products
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MVVPDKISEV VELLKKLPDL ERLLSKIHNV GSPLKSQNHP DSRAIMYEET
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- MSH6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
- Synonyms
- GTBP Peptide, GTMBP Peptide, HNPCC5 Peptide, HSAP Peptide, p160 Peptide, cb326 Peptide, wu:fb36c12 Peptide, LOC100227810 Peptide, AU044881 Peptide, AW550279 Peptide, Gtmbp Peptide, mutS homolog 6 Peptide, mutS homolog 6 (E. coli) Peptide, DNA mismatch repair protein Peptide, MSH6 Peptide, msh6 Peptide, Msh6 Peptide
- Background
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This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Alias Symbols: GTBP, HSAP, p160, GTMBP, HNPCC5
Protein Size: 1360 - Gene ID
- 2956
- NCBI Accession
- NM_000179, NP_000170
- UniProt
- P52701
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