Nuclear Receptor Binding Factor 2 (NRBF2) (Middle Region) Peptide
NRBF2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NRBF2 products
- NRBF2 (Nuclear Receptor Binding Factor 2 (NRBF2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EFLVAENERL RKENKQLKAE KARLLKGPIE KELDVDADFV ETSELWSLPP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- NRBF2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NRBF2 (Nuclear Receptor Binding Factor 2 (NRBF2))
- Synonyms
- COPR1 Peptide, COPR2 Peptide, NRBF-2 Peptide, nuclear receptor binding factor 2 Peptide, NRBF2 Peptide, Nrbf2 Peptide
- Background
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May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation.
Alias Symbols: COPR, COPR1, COPR2, NRBF-2
Protein Size: 287 - Gene ID
- 29982
- NCBI Accession
- NM_001282405, NP_001269334
- UniProt
- Q96F24
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