Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide
GNA12
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GNA12 products
- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IILFLNKMDL LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- GNA12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
- Synonyms
- NNX3 Peptide, RMP Peptide, gep Peptide, gna12 Peptide, gna12l Peptide, AI414047 Peptide, AI504261 Peptide, Galpha12 Peptide, G protein subunit alpha 12 Peptide, guanine nucleotide binding protein (G protein) alpha 12a Peptide, guanine nucleotide binding protein, alpha 12 Peptide, GNA12 Peptide, Gna12 Peptide, gna12a Peptide
- Background
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Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Alias Symbols: RMP, gep, NNX3
Protein Size: 381 - Gene ID
- 2768
- NCBI Accession
- NM_001282441, NP_001269370
- UniProt
- Q03113
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