Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (Middle Region) Peptide
IDH1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5673123
$160.46
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100 μg
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Quick Overview for Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (Middle Region) Peptide (ABIN5673123)
Target
IDH1
(Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- EAAHGTVTRH YRMYQKGQET STNPIASIFA WTRGLAHRAK LDNNKELAFF
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- IDH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
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Background
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: IDH, IDP, IDCD, IDPC, PICD, HEL-216, HEL-S-26
Protein Size: 414 -
Gene ID
- 3417
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NCBI Accession
- NM_001282386, NP_001269315
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UniProt
- O75874
Target
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