Thioredoxin Reductase 1 (TXNRD1) (Middle Region) Peptide
TXNRD1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TXNRD1 products
- TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TGERPRYLGI PGDKEYCISS DDLFSLPYCP GKTLVVGASY VALECAGFLA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- TXNRD1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))
- Synonyms
- TrxR1 Peptide, cb682 Peptide, fb83a08 Peptide, wu:fb83a08 Peptide, GB14972 Peptide, MGC85342 Peptide, NADPH-dependent thioredoxin reductase C Peptide, T32G6.20 Peptide, T32G6_20 Peptide, GRIM-12 Peptide, TR Peptide, TR1 Peptide, TRXR1 Peptide, TXNR Peptide, Tr Peptide, thioredoxin reductase 1 Peptide, thioredoxin reductase 1 L homeolog Peptide, NADPH-dependent thioredoxin reductase C Peptide, ThioRedoXin Reductase Peptide, TXNRD1 Peptide, txnrd1 Peptide, Trxr-1 Peptide, txnrd1.L Peptide, NTRC Peptide, trxr-1 Peptide, Txnrd1 Peptide
- Background
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The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Alias Symbols: TR, TR1, TXNR, TRXR1, GRIM-12
Protein Size: 499 - Gene ID
- 7296
- NCBI Accession
- NM_001093771, NP_001087240
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