BCL2-Associated Athanogene 4 (BAG4) (C-Term) Peptide
Quick Overview for BCL2-Associated Athanogene 4 (BAG4) (C-Term) Peptide (ABIN8095463)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- BAG4 Peptide - C-terminal region
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Sequence
- EVEEFVGKKT DKAYWLLEEM LTKELLELDS VETGGQDSVR QARKEAVCKI
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BCL2-Associated Athanogene 4 (BAG4) peptide
BAG4 Reactivity: Human Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-BAG4 Antibody (ARP61939_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
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Background
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Background Information: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alternative Symbols: BAG-4, SODD
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Molecular Weight
- 50kDa
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Gene ID
- 9530
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NCBI Accession
- NP_004865
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UniProt
- O95429
Target
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