BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Middle Region) Peptide
Quick Overview for BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Middle Region) Peptide (ABIN8095472)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- BCL2L11 Peptide - middle region
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Sequence
- PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP QGPLAPPASP
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
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Background
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Background Information: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
Alternative Symbols: BAM, BIM, BOD
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Molecular Weight
- 22 kDa
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Gene ID
- 10018
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NCBI Accession
- NP_001191035
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UniProt
- O43521
Target
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