Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) Peptide
Quick Overview for Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) Peptide (ABIN8096289)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- CBL Peptide - C-terminal region
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Sequence
- GEGNLAAAHA NTGPEESENE DDGYDVPKPP VPAVLARRTL SDISNASSSF
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Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) peptide
CBL Reactivity: Human, Mouse, Rat, Cow, Dog, Pig Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- CBL Antibody (ARP35761_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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Background
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Background Information: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Alternative Symbols: CBL2, NSLL, C-CBL, RNF55, FRA11B
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Molecular Weight
- 99 kDa
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Gene ID
- 867
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NCBI Accession
- NP_005179
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UniProt
- P22681
Target
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