Crossover junction endonuclease EME1 (EME1) (Middle Region) Peptide
Quick Overview for Crossover junction endonuclease EME1 (EME1) (Middle Region) Peptide (ABIN8098023)
Target
Source
Application
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Protein Region
- Middle Region
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Purpose
- EME1 Peptide - middle region
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-EME1 antibody ( ARP52988_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Crossover junction endonuclease EME1 (EME1)
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Background
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Background Information: EME1 interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. EME1 may be required in mitosis for the processing of stalled or collapsed replication forks.EME1 and MUS81 (MIM 606591) form an endonuclease complex that cleaves branched DNA structures, especially those arising during stalled DNA replication (Abraham et al., 2003 [PubMed 14609959]).[supplied by OMIM].
Alternative Symbols: FLJ31364, MMS4L, SLX2A
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Molecular Weight
- 63kDa
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Gene ID
- 146956
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NCBI Accession
- NP_689676
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UniProt
- Q96AY2
Target
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