Damage Specific DNA Binding Protein 1 (DDB1) (Middle Region) Peptide
Quick Overview for Damage Specific DNA Binding Protein 1 (DDB1) (Middle Region) Peptide (ABIN8098513)
Target
Origin
Source
Application
-
-
Protein Region
- Middle Region
-
Purpose
- DDB1 Peptide - middle region
-
Sequence
- RHVKTYEVSL REKEFNKGPW KQENVEAEAS MVIAVPEPFG GAIIIGQESI
-
-
Damage Specific DNA Binding Protein 1 (DDB1) peptide
DDB1 Reactivity: Human, Mouse, Cow, Dog, Rat Host: Synthetic BP, Imm
-
-
Application Notes
- Optimal working dilution should be determined by the investigator.
-
Comment
-
This is a synthetic peptide designed for use in combination with anti- DDB1 Antibody (ARP87409_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
-
Background
-
Background Information: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Alternative Symbols: XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1
-
Molecular Weight
- 125 kDa
-
Gene ID
- 1642
-
NCBI Accession
- NP_001914
-
UniProt
- Q16531
Target
-
