Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (C-Term) Peptide
Quick Overview for Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) (C-Term) Peptide (ABIN8098869)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- Dkk4 Peptide - C-terminal region
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Sequence
- RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC
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Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) peptide
DKK4 Reactivity: Human, Mouse, Dog, Pig, Rat Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-Dkk4 Antibody (ARP42406_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
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Background
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Background Information: Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alternative Symbols: Dkk-4, MGC25705
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Molecular Weight
- 24kDa
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Gene ID
- 234130
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NCBI Accession
- NP_663567
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UniProt
- Q8VEJ3
Target
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