Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (N-Term) Peptide
Quick Overview for Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (N-Term) Peptide (ABIN8099266)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- DYRK1A Peptide - N-terminal region
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Sequence
- INEVYYAKKK RRHQQGQGDD SSHKKERKVY NDGYDDDNYD YIVKNGEKWM
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-DYRK1A Antibody(ARP45797_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
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Background
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Background Information: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Alternative Symbols: DYRK, DYRK1, HP86, MNB, MNBH, MRD7
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Molecular Weight
- 85kDa
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Gene ID
- 1859
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NCBI Accession
- NP_001387
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UniProt
- Q13627
Target
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