E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Peptide
Quick Overview for E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Peptide (ABIN8099379)
Target
Source
Application
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Purpose
- SIAH1 Peptide
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E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) peptide
SIAH1 Reactivity: Human, Rat, Cow, Dog, Mouse Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-SIAH1 antibody ( ARP38212_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
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Background
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Background Information: SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterizedThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alternative Symbols: SIAH1A
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Molecular Weight
- 31kDa
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Gene ID
- 6477
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NCBI Accession
- NP_003022
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UniProt
- Q8IUQ4
Target
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