erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Middle Region) Peptide
Quick Overview for erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Middle Region) Peptide (ABIN8099821)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- DMTN Peptide - middle region
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Sequence
- SLPAYGRTTL SRLQSTEFSP SGSETGSPGL QNGEGQRGRM DRGNSLPCVL
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- EPB49 Antibody (ARP79851_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
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Background
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Background Information: The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alternative Symbols: DMT, EPB49
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Molecular Weight
- 40 kDa
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Gene ID
- 2039
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NCBI Accession
- NP_001107607
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UniProt
- Q08495
Target
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