Fragile X Mental Retardation 1 (FMR1) (C-Term) Peptide
Quick Overview for Fragile X Mental Retardation 1 (FMR1) (C-Term) Peptide (ABIN8100975)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- Fmr1 Peptide - C-terminal region
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Sequence
- QIGASSRPPP NRTDKEKGYV TDDGQGMGRG SRPYRNRGHG RRGPGYTSES
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Fragile X Mental Retardation 1 (FMR1) peptide
FMR1 Reactivity: Human, Rat, Dog, Mouse Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-Fmr1 Antibody (ARP40379_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- FMR1 (Fragile X Mental Retardation 1 (FMR1))
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Background
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Background Information: Fmr1 is a translation repressor. Fmr1 is a component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs.Fmr1 is associated with polysomes. Fmr1 is involved in the transport of mRNA from the nucleus to the cytoplasm. Fmr1 binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Alternative Symbols: FMRP, Fmr1
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Molecular Weight
- 67kDa
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Gene ID
- 24948
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NCBI Accession
- NP_434691
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UniProt
- Q80WE1
Target
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