Frizzled Family Receptor 4 (FZD4) (C-Term) Peptide
Quick Overview for Frizzled Family Receptor 4 (FZD4) (C-Term) Peptide (ABIN8100993)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- FZD4 Peptide - C-terminal region
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Sequence
- GITSGMWIWS AKTLHTWQKC SNRLVNSGKV KREKRGNGWV KPGKGNETVV
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Frizzled Family Receptor 4 (FZD4) peptide
FZD4 Reactivity: Human, Rat Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- FZD4 Antibody (ARP89714_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- FZD4 (Frizzled Family Receptor 4 (FZD4))
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Background
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Background Information: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.
Alternative Symbols: Fz4
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Molecular Weight
- 60 kDa
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Gene ID
- 14366
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NCBI Accession
- NP_032081
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UniProt
- Q61088
Target
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