Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (N-Term) Peptide
Quick Overview for Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (N-Term) Peptide (ABIN8101343)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- FGR Peptide - N-terminal region
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Sequence
- GDFRSYGAAD HYGPDPTKAR PASSFAHIPN YSNFSSQAIN PGFLDSGTIR
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Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) peptide
FGR Reactivity: Human, Mouse, Rat, Dog Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
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Background
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Background Information: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alternative Symbols: SRC2, c-fgr, c-src2, p55-Fgr, p58-Fgr, p55c-fgr, p58c-fgr,
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Molecular Weight
- 59 kDa
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Gene ID
- 2268
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NCBI Accession
- NP_001036194
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UniProt
- P09769
Target
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