GNAS Complex Locus (GNAS) (N-Term) Peptide
Quick Overview for GNAS Complex Locus (GNAS) (N-Term) Peptide (ABIN8101825)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- GNAS Peptide - N-terminal region
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Sequence
- NSKTEDQRNE EKAQREANKK IEKQLQKDKQ VYRATHRLLL LGAGESGKST
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- GNAS Antibody (ARP89242_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- GNAS (GNAS Complex Locus (GNAS))
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Background
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Background Information: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined.
Alternative Symbols: P1, P2, P3, GSP, Gsa, POH, GPSA, Nesp, SCG6, Gnas1, Nespl, PHP1A, PHP1B, Gnasxl, Nesp55, Oedsml, Galphas, Oed-Sml, Gs-alpha, 5530400H20Rik, A930027G11Rik, C130027O20Rik
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Molecular Weight
- 43 kDa
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Gene ID
- 14683
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NCBI Accession
- NP_001070978
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UniProt
- P63094
Target
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