GTP Cyclohydrolase 1 (GCH1) (N-Term) Peptide
GCH1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN8102001
$145.08
Plus shipping costs $50.00
100 μg
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Quick Overview for GTP Cyclohydrolase 1 (GCH1) (N-Term) Peptide (ABIN8102001)
Target
GCH1
(GTP Cyclohydrolase 1 (GCH1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Purpose
- GCH1 Peptide - N-terminal region
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Sequence
- PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR
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GTP Cyclohydrolase 1 (GCH1) peptide
GCH1 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-GCH1 Antibody (ARP59619_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- GCH1 (GTP Cyclohydrolase 1 (GCH1))
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Background
- This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
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Molecular Weight
- 27kDa
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Gene ID
- 2643
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UniProt
- P30793
Target
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