Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) Peptide
Quick Overview for Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) Peptide (ABIN8102205)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- Hand2 Peptide - C-terminal region
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Sequence
- DQNGEAEAFK AEIKKTDVKE EKRKKELNEI LKSTVSSNDK KTKGRTGWPQ
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-Hand2 Antibody (ARP30571_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))
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Background
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Background Information: Hand2 is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. It is required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. It plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Hand2 is involved in the development of branchial arches, which give rise to unique structures in the head and neck.
Alternative Symbols: AI225906, AI661148, Ehand2, Hed, Th2, Thing2, bHLHa26, dHAND
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Molecular Weight
- 24kDa
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Gene ID
- 15111
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NCBI Accession
- NP_034532
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UniProt
- Q61039
Target
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