Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1) (N-Term) Peptide
Quick Overview for Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1) (N-Term) Peptide (ABIN8102784)
Target
Source
Application
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Protein Region
- N-Term
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Purpose
- RMI1 Peptide - N-terminal region
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-RMI1 antibody ( ARP46340_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))
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Background
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Background Information: RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 BP327553.1 1-136 137-885 DN997105.1 9-757 886-2740 AL732446.4 14777-16631 2741-3508 BC039999.2 2566-3333
Alternative Symbols: BLAP75, C9orf76, FLJ12888, RP11-346I8.1
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Molecular Weight
- 70kDa
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Gene ID
- 80010
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NCBI Accession
- NP_079221
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UniProt
- Q9H9A7
Target
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