Iron-Responsive Element Binding Protein 2 (IREB2) Peptide
Quick Overview for Iron-Responsive Element Binding Protein 2 (IREB2) Peptide (ABIN8103464)
Target
Source
Application
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Purpose
- IREB2 Peptide
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-IREB2 antibody ( ARP40509_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))
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Background
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Background Information: IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Alternative Symbols: ACO3, FLJ23381, IRP2, IRP2AD
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Molecular Weight
- 105kDa
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Gene ID
- 3658
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NCBI Accession
- NP_004127
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UniProt
- P48200
Target
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