Mdc1 (MDC1) (C-Term) Peptide
Quick Overview for Mdc1 (MDC1) (C-Term) Peptide (ABIN8104973)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- MDC1 Peptide - C-terminal region
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Sequence
- GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-MDC1 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MDC1 (Mdc1 (MDC1))
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Background
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Background Information: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Alternative Symbols: DKFZp781A0122, KIAA0170, MGC166888, NFBD1
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Molecular Weight
- 227kDa
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Gene ID
- 9656
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NCBI Accession
- NP_055456
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UniProt
- Q14676
Target
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